The Heart Smart Cellular Energy Enhancer

Do you remember what it felt like to leap out of bed in the morning when you were a kid … especially in the summer when you greeted each day with energy and enthusiasm to spare? Well, imagine how much you’d accomplish today if you had 50% of that energy.

You’d have the stamina you need to achieve your goals, and you’d feel pretty good at the end of the day.

It could be that you need to supplement your diet with D-ribose. We’re hearing more and more about how ribose is a natural, potent energy enhancer, which just might make a difference in how you greet each day.

What is ribose?

D-Ribose (also known as ribose) is a simple sugar produced in the body that is used by all living cells. It is part of the building blocks that form DNA and RNA molecules, and is one of the crucial ingredients in the production of adenosine tri-phospate (ATP).

What is ATP?

In a nutshell, it’s called the “energy currency” of all cells. It’s the body’s primary energy-carrying molecule that assists in the conversion of nutrients into usable energy, which enables your body to function.

During vigorous exercise or times of stress, large amounts of ATP can be depleted in the heart and skeletal muscles. The problem is your heart, muscles, and other organs and tissues do not make ribose very quickly, and it is not stored in the tissues and cells. Additionally, when your heart and muscles are stressed, ribose levels can be so low that they have a difficult time recovering.

The good news is that ribose supplementation stimulates energy synthesis, allowing tissues to regenerate energy stores, giving them the boost they need to function efficiently … so that you have the energy you need to do what you want to do, while feeling good.

Why take supplemental ribose?

Lack of energy is the number one health complaint heard by doctors. The food you eat, the supplements you take, and the amount of exercise and quality of sleep you get all affect your ability to produce energy at the cellular level. But oxidation (free radical production), stress, overwork, and the quality of the air we breathe are some of the biggies that deplete our reserves and energy levels.

Whether you just want an energy boost or you are an athlete wanting to achieve your goal … whether you suffer from chronic fatigue syndrome or congestive heart failure and heart disease, studies show that you can benefit from adding supplemental ribose to your health regimen.

Who can benefit from D-ribose supplementation?

Everyone needs D-ribose because it is an essential ingredient in stimulating natural energy production. It is especially beneficial to older people, athletes, weekend warriors, and those dealing with chronic or unexplained fatigue, fibromyalgia, coronary artery disease, and congestive heart failure.

Benefits

Research has shown that D-ribose may hold numerous benefits for:

  • Heart disease
  • Chronic muscle disease
  • Aging
  • Chronic fatigue syndrome
  • Fibromyalgia
  • Athletic performance and recovery

How does D-ribose work?

The form of D-ribose that the body utilizes is called 5-phosphoribosyl-1-pyrophosphate (PRPP), which regulates the metabolic pathway that synthesizes energy compounds in all living tissue. This pathway is called the Purine Nucleotide Pathway (PNP). But if the body doesn’t have enough PRPP—or D-ribose—energy synthesis slows and tissue recovery is delayed. It is then crucial that ribose levels be replaced.

Scientists have found that supplemental D-ribose can rapidly stimulate the metabolic pathway used by the body to replenish these energy levels, restoring ribose levels in nerves and muscles. This in turn has a positive effect on ATP production in all muscles, especially the heart.

The general theory is that when a person has heart disease, ATP is degraded—which then means there is less energy for the heart to function properly. The heart’s ability to re-synthesize ATP is then limited by the availability of D-ribose. In support of this theory, recent studies have shown that ribose helps patients with myocardial ischemia and exercise-induced angina.1

D-ribose supplementation:

  • Increases the rate of ATP and energy recovery after strenuous exercise, stress, and overwork
  • Shortens the time needed by heart and muscle tissue to replace energy that is lost through stress, exercise, and overwork
  • Helps the heart and muscles maximize energy recovery
  • Increases stamina and endurance, and reduces fatigue

D-Ribose and heart disease

“Congestive heart failure is one of the most common reasons people 65 and older go into the hospital.”

Heart disease is the number one killer in America. According to the American Heart Association, it claimed 871,500 lives in 2004 (36.3 percent of all deaths or 1 of every 2.8 deaths).2  There is good news though. Numerous scientific and clinical studies have shown that D-ribose can help to restore energy and function to the heart. It is especially helpful to those with ischemic cardiovascular disease3—lack of blood flow and oxygen to the heart muscle—and congestive heart failure (CHF).

Congestive heart failure is one of the most common reasons people 65 and older go into the hospital. It can take years for heart failure to develop. So if you don’t yet have it but are at risk for it, adding D-ribose to your health regimen would be an excellent start to improve your health.

What happens when the heart muscle loses its umpf?

When the heart muscle loses energy, first it suffers a loss of diastolic function. This is the relaxation phase when the heart fills with blood for the next heartbeat. When diastolic function is compromised, less blood circulates to the body during each beat, and can lead to hypertrophy; a thickening and expansion of the heart muscle. Additionally, there is inadequate oxygen circulating throughout the body, which causes the heart to overcompensate by using energy faster than it normally does. This results in a depletion of cellular energy reserves. Ultimately, it becomes a vicious cycle in which a loss of cardiac energy leads to a loss of heart function.

“An increased cellular demand for ATP can severely affect the body’s biochemistry, which may take several days to recover or may not recover at all in cases of chronic ischemia.”

Congestive heart failure is often the result of chronic diastolic dysfunction. Symptoms include shortness of breath, loss of exercise capacity, and overwhelming fatigue.

Research has also shown that intense endurance exercise puts a big strain on the heart, contributing to a loss of diastolic heart function that can continue for weeks or months following an athletic event such as a marathon or triathalon. An increased cellular demand for ATP can severely affect the body’s biochemistry, which may take several days to recover or may not recover at all in cases of chronic ischemia. Supplemental ribose, however, can enhance the recovery of heart and muscle ATP levels.4

Scientific studies

A study of 15 patients with chronic coronary artery disease and congestive heart failure who were given D-ribose for three weeks found that the supplement improved diastolic functional parameters and enhanced their quality of life.5

A German study demonstrated that D-ribose supplementation is effective in increasing the heart’s tolerance to ischemia. Twenty patients diagnosed with coronary artery disease completed two treadmill tests on consecutive days to establish pain thresholds for each patient. The researchers then gave each patient 60 grams of ribose per day for three days, plus another treadmill test. The patients who took ribose were able to walk further before experiencing pain than those given the placebo.6

“D-ribose is a powerful fatigue fighter—20% of Americans suffer from fatigue that interferes with their normal life.”

Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome is the diagnosis used to describe fatigue that lasts more than six months and can’t be attributed to any other illness. It affects more than one million people in the U.S. Although it is more common in people in their 40s and 50s, it can occur in any age, gender, ethnicity, or socioeconomic group. The symptoms usually include four or more of the following:

  • Sore throat
  • Impaired short-term memory and/or concentration
  • Tender lymph nodes
  • Joint pain without swelling or redness
  • Muscle pain
  • Headaches
  • Unrestful sleep

Scientific studies

Fibromyalgia and chronic fatigue syndrome are debilitating syndromes that are often associated with impaired cellular energy metabolism. An uncontrolled pilot study of 41 patients was done to see if ribose could improve symptoms of fibromyalgia and/or chronic fatigue.

66% of the patients with a diagnosis of fibromyalgia and/or chronic fatigue syndrome who took D-ribose showed an improvement in their energy, sleep, mental clarity, pain tolerance, and sense of well-being. Among these patients, their energy levels increased about 45% and they experienced an average 30% boost in overall well-being. The researchers concluded that ribose significantly reduced clinical symptoms in these patients suffering from fibromyalgia and chronic fatigue syndrome.7

An article that appeared in the 2004 issue of Journal of Pharmacology highlighted a case study about a fibromyalgia patient who added supplemental D-ribose to her regimen and subsequently had a significant decrease in symptoms.8

Ribose and athletic performance

Free radicals are produced during intense exercise. Based on this theory and the theory that ribose is present in ATP, and that increasing adenine nucleotide availability may enhance high intensity exercise capacity, ribose supplements have been popular with athletes and active individuals for many years. However, there have only been a few clinical studies done that prove this theory.

Scientific studies

In one study D-ribose (10g/d) was shown to increase athletic performance and muscular strength in healthy, young male recreational bodybuilders after four weeks. No significant changes in their body composition were noted, and there were no changes at all found in the men who took a placebo.9

Another study of seven healthy men who did two ergometric sessions (stress tests to determine physiology) on a bicycle to exhaustion at a one-week interval indicated that D-ribose improved the efficiency of their energy production.

Before the second test, the men took seven grams of ribose, which resulted in a reduction of urinary MDA—an indicator of oxidation and lower heart rates, when compared to the group who didn’t take the D-ribose supplement.10

What should I look for in a D-ribose supplement?

Look for a D-ribose product that contains pure ingredients in an easy-to-use powder form. It should contain proven amounts that have shown to be effective in research studies. Dosage in these studies typically ranged between 5-60 grams daily.

Conclusion

Most tissues in the body—especially the heart—are unable to produce ribose fast enough to restore levels once they’ve been depleted. It’s a matter of supply and demand. Just as a car battery needs enough fluid to keep it charged and running, your body needs plenty of ribose to help it produce the ATP that supplies cells with an energy current.

So whether you suffer from chronic fatigue syndrome or congestive heart failure or heart disease … or whether you just want an energy boost or are an athlete wanting to achieve your goals, consider adding supplemental D-ribose to your health regimen for the energy boost that might make a big difference in your life.

Slow Aging with Nicotinamide Mononucleotide (NMN)

Complements of the Phytocopeia Natural Products Formulary

What is Nicotinamide Mononucleotide?

Nicotinamide Mononucleotide or NMN is an organic molecule advertised as a kind of “Fountain of Youth” natural supplement. The reason is based on how it acts as a precursor to nicotinamide adenine dinucleotide or NAD. 

NAD boosts cellular energy production (ATP), promote efficient metabolism, improves sleep and recovery, and benefits hundreds of other enzymatic reactions crucial to everyday life.

We also lose NAD as we age, and scientists hypothesize that increasing NAD levels could help delay ageing. [1]

Food Sources of Nicotinamide Mononucleotide

Since we can’t exactly eat NAD, primarily because the human body wasn’t designed to absorb NAD through digestion, the next best thing is to get NMN from food sources. Some of these sources are edamame, broccoli, cucumbers, cabbage, avocado, and tomatoes.

While getting NMN from our diet is possible, it’s not very efficient since NMN can only be found in trace amounts. This is where supplementation comes in.

Performance and Health Benefits of Taking Nicotinamide Mononucleotide

So, what does supplementing NMN do for you? 

Nicotinamide Mononucleotide helps slow down aging

The biggest reason why NMN supplements are flying off shelves is how it was studied as an anti-aging supplement. As mentioned, it works by boosting NAD levels, a compound that naturally declines with age. Therefore, boosting NAD levels can indirectly lead to a longer lifespan. [2]

It also seems to work on other factors that affect aging such as telomere length – a tail of our DNA that shortens as we age – and sirtuin activity – a family of molecules that exhibit antioxidant properties, fight cellular aging, lower DNA damage, and is involved in complex anti-aging processes.

Nicotinamide Mononucleotide Improves quality of life

Some scientists believe taking NMN supplements can help with slowing aging as well as improving our overall health, especially when it comes to lowering cholesterol and triglyceride levels. It’s also been highlighted to promote physical activity.

Other studies note that it can possibly provide better eyesight for those who have trouble reading without glasses. 

These findings demonstrate that NAD+ biosynthesis is essential for vision, provide a foundation for future work to further clarify the mechanisms involved, and identify a unifying therapeutic target for diverse blinding diseases.[3]

Nicotinamide Mononucleotide Promotes heart health

Some studies show NMN supplements help restore damaged heart tissue as well as reverse blood vessel damage caused by aging. These resulted in better blood flow as well as a stronger heart overall. 

In the present study, 8 weeks of NMN supplementation restored a marker of arterial SIRT1 activity and ameliorated age‐associated endothelial dysfunction and large elastic artery stiffening in male C57Bl/6 mice.[4]

Limitations

While Nicotinamide Mononucleotide supplementation seems promising, it has to be noted that all the studies used and all the positive results were derived from mostly using mice as subjects.

Many studies regarding supplements used animal subjects and drew positive results in humans, but that’s not to say it works the same way all the time. 

Summary

Nicotinamide Mononucleotide is an important molecule known to promote chemical reactions and processes inside the body that help fight aging.

You can always supply the body with Nicotinamide Mononucleotide from dietary sources, but the most efficient way is to take Nicotinamide Mononucleotide supplements.

Studies show Nicotinamide Mononucleotide supplementation has great benefits with regards to slowing aging as well as overall quality of life and heart health. While the majority of studies do revolve around mice subjects, test results are promising and shouldn’t discourage consumers.

References:

  1. Poddar SK, Sifat AE, Haque S, Nahid NA, Chowdhury S, Mehedi I. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. Biomolecules. 2019;9(1):34. Published 2019 Jan 21. doi:10.3390/biom9010034
  2. Kawamura T, Mori N, Shibata K. β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats. J Nutr Sci Vitaminol. 2016;62(4):272-276
  3. Lin JB, Kubota S, Ban N, et al. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016;17(1):69–85. doi:10.1016/j.celrep.2016.08.073
  4. de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522–530. doi:10.1111/acel.12461

Use of Vitamin C in the Treatment of COVID-19 and Other Viruses

Virus
Vitamin C in Treatment of COVID-19 and Other Viruses

The Orthomolecular Medicine News Service points out that epidemics seem to be on the rise. In a total of 98 epidemics in the 200 years of 19th and 20th centuries, there were 14 epidemics with 1000 or more deaths. However, in the last 20 years, in a total of 63 epidemics, there have already been 11 epidemics with more than 1,000 deaths. 

Be safe, stay well, and be sure to share the important information in this article.

Orthomolecular Medicine Rationale for Vitamin C Treatment of COVID-19 and Other Viruses

Growth Hormone – Essential to Health – Declines With Age

Pituitary Gland

Growth hormone (GH) is involved in a wide variety of activities essential to health, including the repair of damaged tissue in bones, organs and muscles; maintaining muscle mass; insulin sensitivity and burning fat; promoting strong immune defenses; and supporting healthy blood vessels, blood pressure and cholesterol levels.

GH is produced by the pituitary gland, which secretes tiny amounts throughout the day and night in a series of pulses. Total daily GH secretion peaks around puberty and begins to decline by age 21, until, by age 60, most adults, despite the fact that their pituitary is still producing GH, have total 24-hour GH secretion rates indistinguishable from those of younger patients with severely compromised pituitary function.1

Why restore GH secretion to more youthful levels?

Aging adults, even those receiving hormone replacement therapy with DHEA, thyroid, estrogen and/or testosterone, still frequently report fatigue, lethargy, and decreased strength and exercise tolerance. Plus, several recent large population studies show the risk of cardiovascular disease and death is significantly increased in adults whose circulating levels of GH are very low.

Click here to read more . . .

Have You Heard of Metabolic Syndrome?

vitality

If you have not yet heard of Metabolic Syndrome, there is an article on the website that very well might save your life.  Metabolic Syndrome is a combination of four conditions.  Having any one of these conditions alone is a threat to your health.   Having two, three or all four conditions – full blown Metabolic Syndrome – could be disastrous!  But there is hope for those who suffer from Metabolic Syndrome.  I like to think of it as “Metabolic Rescue” and I detail the conditions and the natural solutions in the article… Metabolic Rescue: Breaking the Epidemic of the Metabolic Syndrome Cycle!

To your health,

Us Smart Publications

Health Care Needs to be About Us!

For all of us!

Not about profits and market expansion

In today’s political environment, we the people are losing ground. Whether you’re on the right or left, up or down on where we are heading, or have chosen to withdraw from any part of the conversation, it’s hard not to notice. We’re losing focus on individuals, losing focus on us.

Nowhere is this more obvious than health care, or more specifically, the pharmaceutical markets. What we are told and prescribed is first dictated by financial projection, and then by investment, in support of capitalism. And while this is a great system supporting industrial advancement, it can leave some good ideas, and some of us good people behind.

Many natural methods we once used to support health have been replaced with synthetic patented drugs. The once valid argument of protecting and supporting investment in research to supply the masses with needed medicines is now overshadowed with the cost of patent protection and government oversight, as well as the need to meet market expectations.

As drug patents expire, so does the incentive to manufacture, promote, and distribute. The profits will be in what’s next, not what is – or was.

Here are a few things to consider:

  • Did the drugs of yesteryear stop working?
    • Usually not.
  • Will the drugs of tomorrow out perform the drugs of today?
    • Maybe . . . most likely from an investor standpoint.
  • Has the idea of continuous improvement moved away from the product to focus only on the money?
    • Not completely, but it is the money that is the first consideration. And without a windfall in that consideration, the product simply won’t follow.

Here are parts of a conversation once overheard:

“We have developed a cure for XXXXXXXX which is a rare crippling disease”
“You said rare, how rare?”
“XXXXXXX people contract this annually”
“Not enough, what else do you have?”

Was this a greedy entrepreneur with no morals? No, just a knowledgeable business person that knows the cost of FDA approval and current patent laws do not allow for a compassionate approach.

We’ve all heard the expression “money makes the world go round.” How about a new phrase “big money brings our health care down?”

The goal of Us Smart Publications is to provide alternative health care information for us – for all of us.

Best in health,
Us Smart Publications

Taurine – The Amino Acids That Roars!

Dear Reader,

If you have a cat, you may be familiar with taurine. This amino acid is added to your pet’s food because without it cats develop dramatic health problems, including reproductive failure, growth retardation, retinal degeneration and heart failure.

But whether you have a cat or not, you’ll definitely want to learn how the amino acid that improves the nutritional health of our feline friends can help us humans live a life with added protection from:

  • Congestive heart failure
  • High blood pressure
  • Brain aging
  • Muscle damage (due to strenuous activity)
  • Diabetes
  • Retinal damage

Additionaly, regular users of taurine report that:

  • It is relaxing
  • It improves sleep
  • It regulates the heartbeat and eliminates palpitations
  • It helps detoxify the body

While we may not gain nine lives from taurine supplements, it seems certain—based on new and continuing research into this remarkable amino acid—that it can improve the health of our one life.

Taurine is much more than “the cat’s meow” of amino acids—it is a powerful addition to your supplement program. To learn more about the health benefits of taurine, please read the article Taurine Protects Heart, Eyes and Improves Glucose Tolerance.

To your health,

 

Us Smart Publications

Knowing The Different Forms Of Vitamin E Is The Key To Good Health!

Dear Reader,

You’ve heard about the numerous benefits of vitamin E supplements.  But you won’t reap those benefits unless you’re taking high amounts of a particular subtype of vitamin E called gamma tocopherol.

Most progressive nutritional supplement companies offer vitamin E supplements that claim to contain “Mixed tocopherols” or “Full Spectrum” tocopherols.

But these terms don’t mean much in and of themselves, because they don’t tell you exactly how much gamma tocopherol is in the product.

Furthermore, we know for a fact that the raw materials market offers many so called “mixed tocopherol” products that contain only small amounts of the rather expensive gamma tocopherol. They are in fact “mixed” … they just don’t contain a meaningful amount of the stuff you really want!

To set the record straight regarding  exactly what to look for in a superb vitamin E supplement,  please read the article, Are You Taking the Wrong Vitamin E? Get the Facts on Vitamin E Tocopherols!

To your health,

Us Smart Publications

Brain Nutrition Update: Choline + Uridine Builds New Neurons!

Dear Reader,

Scientists continue to vigorously explore the frontier of cognitive enhancement.  In this special update on brain nutrition, you’ll learn about two remarkable “next generation” nutrients, and why scientists are especially excited about their ability to protect and repair delicate brain cells and membranes, slow down brain aging, and support memory and cognitive function.

These two nutrients, choline and uridine, work together to repair, maintain, and build neuro-pathways.  Please read
Choline + Uridine Builds New Neurons!
To your health,

Us Smart Publications

Adrenal Glands Play an Important Role in Allergic Response

Dear Reader,

Allergic reactions are one of the most typical signs of an imbalanced immune system. And an overly sensitive immune system may be the result of weakened adrenal glands.

According to adrenal health expert  Dr. James L. Wilson, author of Adrenal Fatigue: The 21st Century Stress Syndrome,  most allergies involve the release of histamine and other substances that produce inflammation. In his book, Dr. Wilson writes that, “Cortisol is a strong anti-inflammatory. Your circulating level of cortisol is the key factor in the level of inflammatory reactions in your body. For this reason your adrenal glands play an important role in mediating the histamine release and inflammatory reactions that produce the symptoms experienced with allergies. It is therefore not surprising that people with food and environmental allergies commonly have weak adrenal function.”

Dr. Wilson, who also holds a Ph.D. in human nutrition, continues:

•The more histamine that is released, the more cortisol it takes to control the inflammatory response and the harder the adrenals have to work to produce more cortisol.

• The harder the adrenals have to work the more fatigued they become and the less cortisol they produce, allowing histamine to inflame the tissues more.

• The vicious circle can lead to progressively deeper adrenal fatigue as well as to larger allergic reactions.

• Anything that you can do to break this cycle will help your adrenal glands and reduce the effects of allergies.

How do you break the cycle in order to help your adrenal glands and get relief from allergies? To find out, please read Adrenal Fatigue: The 21st Century Stress Syndrome.

To your health,

US Smart Publications